Synthesis of 2,3-disubstituted pyrrolidines by intramolecular addition of α-aminoalkyl radicals to electron deficient C=C bonds

被引：41

作者：

Aurrecoechea, JM ^{[1
]}

Fernández, A ^{[1
]}

Gorgojo, JM ^{[1
]}

Saornil, C ^{[1
]}

机构：

[1] Univ Basque Country, Fac Ciencias, Dept Quim Organ, E-48080 Bilbao, Spain

来源：

TETRAHEDRON | 1999年 / 55卷 / 23期

关键词：

cyclization; pyrrolidines; radicals; samarium;

D O I：

10.1016/S0040-4020(99)00359-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,3-Disubstituted pyrrolidines are prepared by SmI2-pranoted cyclization of alpha-amino radicals generated from N-(alpha-benzotriazolylalkyl)alkenylamines containing a C=C bond activated by an electron withdrawing substituent. The diastereoselectivity of cyclization is moderate and depends on the nature of the substituent at the pyrrolidine 2-position. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7345 / 7362

页数：18

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