Polycystin channels and kidney disease

被引：33

作者：

Stayner, C ^{[1
]}

Zhou, J ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Inst Med, Dept Med,Renal Div, Boston, MA 02115 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0165-6147(00)01832-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polycystins are a distinct family of integral membrane proteins, related by sequence and structural homology. These proteins play important roles in organ morphogenesis and function, and mutations in two of the five known members cause a common renal cystic disease. Recent data on the function of polycystins have revealed them to be Ca2+-permeable cation channels and putative ion-channel regulators. Their roles in the regulation of intracellular Ca2+ concentration and in polycystic kidney disease are discussed.

引用

页码：543 / 546

页数：4

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