Pilomyxoid astrocytoma in a patient with neurofibromatosis

被引：17

作者：

Khanani, MF

Hawkins, C

Shroff, M

Dirks, P

Capra, M

Burger, PC

Bouffet, E

机构：

[1] Hosp Sick Children, Dept Hematol Oncol, Paediat Brain Tumor Programme, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Dept Pathol, Toronto, ON M5G 1X8, Canada

[3] Hosp Sick Children, Dept Radiol, Toronto, ON M5G 1X8, Canada

[4] Hosp Sick Children, Dept Neurosurg, Toronto, ON M5G 1X8, Canada

[5] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

来源：

PEDIATRIC BLOOD & CANCER | 2006年 / 46卷 / 03期

关键词：

astrocytoma; chemotherapy; child; neurofibromatosis; pilomyxoid;

D O I：

10.1002/pbc.20391

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pilomyxoid astrocytoma (PMA), a recently described variant of low-grade astrocytoma is associated with a high rate of recurrence and a propensity for CSF seeding. While cases of PMA have been reported in infants and young children, there has been no report of PMA in patients with neurofibromatosis. The first reportable case of PMA occurring in a child with neurofibrornatosis type 1 (NF1) is described. Following presentation with obstructive hydro-cephalus, the patient underwent a partial resection of a third ventricular tumor. Histology confirmed the typical features of PNAA. The patient demonstrated a partial response to chemotherapy. The authors review the literature on PMA and discuss the specific issues associated with this diagnosis in the context of a child with neurofibromatosis.

引用

页码：377 / 380

页数：4

共 25 条

[1]

Arslanoglu A, 2003, AM J NEURORADIOL, V24, P1906

[2] THE USE OF THE MONOCLONAL-ANTIBODY KI-67 IN THE IDENTIFICATION OF PROLIFERATING CELLS - APPLICATION TO SURGICAL NEUROPATHOLOGY [J].