Molecular diversity of neuronal nicotinic acetylcholine receptors

被引：87

作者：

McGehee, DS ^{[1
]}

机构：

[1] Univ Chicago, Dept Anesthesia & Crit Care, Chicago, IL 60637 USA

来源：

MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS | 1999年 / 868卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb11330.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The potent behavioral and cognitive effects of nicotine highlight the physiological importance of nicotinic acetylcholine receptors (nAChRs). These receptors are part of the superfamily of neurotransmitter-gated ion channels that are responsible for rapid intercellular communication. Molecular cloning of the protein subunits that make up these receptors has led to greater understanding of the pharmacology and physiology of nAChRs. This review outlines our current understanding of the molecular constituents of these receptors and some of the recent studies of the structural determinants of receptor function.

引用

页码：565 / 577

页数：13

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