An update on the genetics of schizophrenia

被引：121

作者：

Norton, N ^{[1
]}

Williams, HJ ^{[1
]}

Owen, MJ ^{[1
]}

机构：

[1] Cardiff Univ, Dept Psychol Med, Wales Sch Med, Cardiff CF14 4XN, Wales

来源：

CURRENT OPINION IN PSYCHIATRY | 2006年 / 19卷 / 02期

基金：

英国医学研究理事会;

关键词：

association; DTNBP1; NRG1; schizophrenia;

D O I：

10.1097/01.yco.0000214341.52249.59

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Purpose of review This paper reviews recent molecular genetic studies of schizophrenia and evaluates claims implicating specific genes as susceptibility loci. Recent findings Molecular genetic studies have identified several potential regions of linkage and two associated chromosomal abnormalities, and the evidence is accumulating in favour of several positional candidate genes. Currently, the strongest evidence for putative schizophrenia susceptibility loci relates to the genes encoding dysbindin (DTNBP1) and neuregulin (NRG1). For other genes, disrupted in schizophrenia (DISC1), D-amino acid oxidase activator (DAOA), regulator of G-protein signalling 4 (RGS4) and V-AKT murine thymoma viral oncogene homolog 1 (AKT1) the data are promising but not yet compelling. In the most convincing cases, the risk haplotypes appear to be associated with small effect sizes and do not fully explain the linkage findings that prompted each study. Summary The ability of positional genetics to implicate novel genes and pathways will open up new vistas for neurobiological research. Despite the accumulation of significant genetic data, however, the susceptibility variants have yet to be identified and detailed follow-up studies are now required.

引用

页码：158 / 164

页数：7

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