A class of highly polymorphic tetranucleotide repeats for canine genetic mapping

被引：280

作者：

Francisco, LV

Langston, AA

Mellersh, CS

Neal, CL

Ostrander, EA

机构：

[1] FRED HUTCHINSON CANC RES CTR,PROGRAM TRANSPLANTAT BIOL,CLIN RES DIV M318,SEATTLE,WA 98104

[2] FRED HUTCHINSON CANC RES CTR,PROGRAM MOLEC MED,SEATTLE,WA 98104

来源：

MAMMALIAN GENOME | 1996年 / 7卷 / 05期

关键词：

D O I：

10.1007/s003359900104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified and characterized a new class of polymorphic markers for the canine genome from a simple tetranucleotide repeat sequence, (GAAA)(n). Genetic markers derived from this repeat are highly polymorphic compared with other canine microsatellites, yet are stable enough to be useful for following Mendelian inheritance in multigeneration pedigrees. We show further that (GAAA)(n) repeats are distributed throughout the canine genome and occur with sufficient frequency to be useful in the development of a framework map of the canine genome.

引用

页码：359 / 362

页数：4

共 23 条

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