An efficient preparation of protected ribonucleosides for phosphoramidite RNA synthesis

被引：48

作者：

Serebryany, V ^{[1
]}

Beigelman, L ^{[1
]}

机构：

[1] Ribozyme Pharmaceut Inc, Dept Organ Chem, Boulder, CO 80301 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(02)00181-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of protected ribonucleosides useful for phosphoramidite RNA synthesis is described. Di-t-butylsilylene group was employed for simultaneous protection of 3'- and 5'-hydroxyl functions of nucleoside, Subsequent silylation of free 2'-OH group followed by introduction of suitable protection on the base moiety. removal of cyclic silyl protection and tritylation of 5'-OH gave target compounds in 60-66%. overall yield. (C) 2002 Elsevier Science Ltd, All rights reserved.

引用

页码：1983 / 1985

页数：3

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