The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice

被引:488
作者
Price, MP
McIlwrath, SL
Xie, JH
Cheng, C
Qiao, J
Tarr, DE
Sluka, KA
Brennan, TJ
Lewin, GR
Welsh, MJ [1 ]
机构
[1] Univ Iowa, Coll Med, Howard Hughes Med Inst, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
[3] Univ Iowa, Coll Med, Grad Program Phys Therapy, Iowa City, IA 52242 USA
[4] Univ Iowa, Coll Med, Dept Anesthesia, Iowa City, IA 52242 USA
[5] Univ Iowa, Coll Med, Dept Physiol & Biophys, Iowa City, IA 52242 USA
[6] Max Delbruck Ctr Mol Med, Dept Neurosci, Growth Factors & Regenerat Grp, D-13092 Berlin, Germany
关键词
D O I
10.1016/S0896-6273(01)00547-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cation channels in the DEG/ENaC family are proposed to detect cutaneous stimuli in mammals. We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception. Disrupting the mouse DRASIC gene altered sensory transduction in specific and distinct ways. Loss of DRASIC increased the sensitivity of mechanoreceptors detecting light touch, but it reduced the sensitivity of a mechanoreceptor responding to noxious pinch and decreased the response of acid- and noxious heat-sensitive nociceptors. The data suggest that DRASIC subunits participate in heteromultimeric channel complexes in sensory neurons. Moreover, in different cellular contexts, DRASIC may respond to mechanical stimuli or to low pH to mediate normal touch and pain sensation.
引用
收藏
页码:1071 / 1083
页数:13
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