Dynamic temporal and spatial regulation of the cdk inhibitor p57kip2 during embryo morphogenesis

被引：37

作者：

Westbury, J ^{[1
]}

Watkins, M ^{[1
]}

Ferguson-Smith, AC ^{[1
]}

Smith, J ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biol Sci, Birmingham B15 2TT, W Midlands, England

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 109卷 / 01期

关键词：

Beckwith-Weidemann syndrome; p57kip2; cell cycle; cyclin dependent kinase inhibitor; apoptosis; programmed cell death; cell cycle control; localization; protein distribution; embryonic; organogenesis; kidney; lung development; omphalocele; placenta; skeletal muscle; mosaicism; mouse development; embryogenesis; insulin-like growth factor; genomic imprinting; morphogenesis;

D O I：

10.1016/S0925-4773(01)00512-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complete developmental expression pattern of the cyclin dependent kinase inhibitor (CDKI) p57(kip2) has not been reported, here we report a detailed study of the localization of p57(kip2) protein during mouse organogenesis. We show that p57(kip2) is coincident with key stages of differentiation of several organs, some but not all of which are affected in Beckwith-Weidermann syndrome, a human congenital syndrome characterized by foetal overgrowth and childhood tumours. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：83 / 89

页数：7

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