BMP stimulation of bone response adjacent to titanium implants in vivo

被引:77
作者
Bessho, K
Carnes, DL
Cavin, R
Chen, HY
Ong, JL
机构
[1] Univ Texas, Hlth Sci Ctr, Dept Restorat Dent, Div Biomat, San Antonio, TX 78284 USA
[2] Psychol Corp, San Antonio, TX 78230 USA
[3] Kyoto Univ, Fac Med, Dept Oral & Maxillofacial Surg, Sakyo Ku, Kyoto 606, Japan
[4] Univ Texas, Hlth Sci Ctr, Dept Endodont, San Antonio, TX 78284 USA
关键词
bone morphogenetic protein; dental implant; reverse torque strength; bone-implant interface;
D O I
10.1034/j.1600-0501.1999.100304.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The objective of this study was to evaluate the effect of bone morphogenetic protein (BMP) on the bond strength of titanium (Ti) implants at the bone-implant interface. Thirty-six Branemark screw implants (3.75 mm diameter by 15 mm long) were implanted for 3 and 12 weeks. At 3 weeks after implantation, the mean reverse torque value for implants stimulated with BMP delivered using an atelopeptide type-I collagen carrier (74.2 +/- 5.2 N cm) was observed to be statistically greater (P < 0.000016) than the mean reverse torque value for control Ti implants (32.8 +/- 1.1 N cm). Similarly, at 12 weeks after implantation, the mean reverse torque value for implants stimulated with BMP (89.2 +/- 2.7 N cm) was statistically greater (P < 0.0042) than the mean reverse torque value for control Ti implants (75.8 +/- 2.4 N cm). In addition, histomorphometric evaluations indicated more bone contact with the BMP stimulated implant surfaces compared to the controls after 3 weeks implantation. It was concluded from this study that the use of BMP-atelopeptide type-I collagen mixture is an effective means of obtaining greater bond strength at the bone-implant interface within a shorter time period than Ti implants without BMP.
引用
收藏
页码:212 / 218
页数:7
相关论文
共 23 条
[1]   MONOSTOTIC FIBROUS DYSPLASIA WITH INVOLVEMENT OF THE MANDIBULAR CANAL [J].
BESSHO, K ;
TAGAWA, T ;
MURATA, M ;
KOMAKI, M .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1989, 68 (04) :396-400
[2]   PURIFICATION OF BONE MORPHOGENETIC PROTEIN DERIVED FROM BOVINE BONE-MATRIX [J].
BESSHO, K ;
TAGAWA, T ;
MURATA, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (02) :595-601
[3]   ACTIVITY AND SOLUBILITY OF BONE MORPHOGENETIC PROTEIN-DERIVED FROM PORCINE BONE-MATRIX [J].
BESSHO, K ;
IIZUKA, T .
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 1994, 32 (02) :86-90
[4]   TRANSMEMBRANE BONE MORPHOGENESIS BY IMPLANTS OF DENTIN MATRIX [J].
CONOVER, MA ;
URIST, MR .
JOURNAL OF DENTAL RESEARCH, 1979, 58 (09) :1911-1911
[5]  
Cook S D, 1995, J Oral Implantol, V21, P281
[6]  
Gotfredsen K, 1992, Clin Oral Implants Res, V3, P77, DOI 10.1034/j.1600-0501.1992.030205.x
[7]  
JACOBSTEIN N, 1988, COUPLING SYMBOLIC NU, V2, P3
[8]  
Johansson C, 1987, Int J Oral Maxillofac Implants, V2, P69
[9]   COMPARATIVE-STUDY OF HYDROXYAPATITE AND TITANIUM DENTAL IMPLANTS IN DOGS [J].
KOHRI, M ;
COOPER, EP ;
FERRACANE, JL ;
WAITE, DF .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1990, 48 (12) :1265-1273
[10]   TENSILE-STRENGTH OF THE INTERFACE BETWEEN HYDROXYAPATITE AND BONE [J].
LIN, H ;
XU, HC ;
DEGROOT, K .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1992, 26 (01) :7-18