BB rat lyp mutation and type 1 diabetes

被引：51

作者：

Ramanathan, S

Poussier, P

机构：

[1] Univ Toronto, Univ Hlth Network, Arthrit & Immune Disorder Res Ctr, Toronto, ON, Canada

[2] Univ Toronto, Dept Med, Toronto, ON, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada

来源：

IMMUNOLOGICAL REVIEWS | 2001年 / 184卷

关键词：

D O I：

10.1034/j.1600-065x.2001.1840115.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BioBreeding (BB) rats spontaneously develop an autoimmune diabetic syndrome similar to that observed in humans and NOD mice. One of the diabetes susceptibility loci maps to the lyp locus on chromosome 4. In this article we describe the consequences of the BB rat lyp mutation on T-cell homeostasis, repertoire and function, as well as its role in the pathogenesis of type I diabetes.

引用

收藏

页码：161 / 171

页数：11

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