Total synthesis of polyamine toxin HO-416b utilizing the 2-nitrobenzenesulfonamide protecting group

被引：59

作者：

Hidai, Y ^{[1
]}

Kan, T ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, CREST, Japan Sci & Technol Corp, Grad Sch Pharmaceut Sci,Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 25期

关键词：

HO-416b; polyamine toxin; 2-nitrobenzenesulfonamide (Ns); solid support;

D O I：

10.1016/S0040-4039(99)00851-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of HO-416b (1) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. Starting with monosulfonylated diamines 2 and 3, three C-N bonds were constructed via alkylation of sulfonamides with alkyl halides. Removal of the Ns groups while the substrate was attached to a novel solid support enabled the efficient isolation of pure 1. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4711 / 4714

页数：4

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