Engineered biosynthesis of structurally diverse tetraketides by a trimodular polyketide synthase

被引：70

作者：

Kao, CM

Luo, GL

Katz, L

Cane, DE

Khosla, C

机构：

[1] BROWN UNIV,DEPT CHEM,PROVIDENCE,RI 02912

[2] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305

[3] STANFORD UNIV,DEPT CHEM,STANFORD,CA 94305

[4] STANFORD UNIV,DEPT BIOCHEM,STANFORD,CA 94305

[5] ABBOTT LABS,ANTIINFECT DISCOVERY RES,ABBOTT PK,IL 60064

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 118卷 / 38期

关键词：

D O I：

10.1021/ja9617552

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：9184 / 9185

页数：2

共 20 条

[1] A MUTANT GENERATED BY EXPRESSION OF AN ENGINEERED DEBS1 PROTEIN FROM THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE (PKS) IN STREPTOMYCES-COELICOLOR PRODUCES THE TRIKETIDE AS A LACTONE, BUT THE MAJOR PRODUCT IS THE NOR-ANALOG DERIVED FROM ACETATE AS STARTER ACID [J].

BROWN, MJB ;

CORTES, J ;

CUTTER, AL ;

LEADLAY, PF ;

STAUNTON, J .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (15) :1517-1518

[2] MACROLIDE BIOSYNTHESIS .4. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO ERYTHROMYCIN [J].

CANE, DE ;

YANG, CC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) :1255-1257

[3] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].

CORTES, J ;

HAYDOCK, SF ;

ROBERTS, GA ;

BEVITT, DJ ;

LEADLAY, PF .

NATURE, 1990, 348 (6297) :176-178

[4] REPOSITIONING OF A DOMAIN IN A MODULAR POLYKETIDE SYNTHASE TO PROMOTE SPECIFIC CHAIN CLEAVAGE [J].

CORTES, J ;

WIESMANN, KEH ;

ROBERTS, GA ;

BROWN, MJB ;

STAUNTON, J ;

LEADLAY, PF .

SCIENCE, 1995, 268 (5216) :1487-1489

[5] READILY ACCESSIBLE 12-I-5 OXIDANT FOR THE CONVERSION OF PRIMARY AND SECONDARY ALCOHOLS TO ALDEHYDES AND KETONES [J].

DESS, DB ;

MARTIN, JC .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (22) :4155-4156

[6] AN ERYTHROMYCIN ANALOG PRODUCED BY REPROGRAMMING OF POLYKETIDE SYNTHESIS [J].

DONADIO, S ;

MCALPINE, JB ;

SHELDON, PJ ;

JACKSON, M ;

KATZ, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7119-7123

[7] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].

DONADIO, S ;

STAVER, MJ ;

MCALPINE, JB ;

SWANSON, SJ ;

KATZ, L .

SCIENCE, 1991, 252 (5006) :675-679

[8] BIOSYNTHESIS OF THE ERYTHROMYCIN MACROLACTONE AND A RATIONAL APPROACH FOR PRODUCING HYBRID MACROLIDES [J].

DONADIO, S ;

STAVER, MJ ;

MCALPINE, JB ;

SWANSON, SJ ;

KATZ, L .

GENE, 1992, 115 (1-2) :97-103

[9]

Evans D.D., 1982, P1

[10] TOTAL SYNTHESIS OF THE POLYETHER ANTIBIOTIC X-206 [J].

EVANS, DA ;

BENDER, SL ;

MORRIS, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (08) :2506-2526

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