Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection

被引：82

作者：

Chiou, CC

Chung, WH

Hung, SI

Yang, LC

Hong, HS

机构：

[1] Chang Gung Mem Hosp, Dept Dermatol, Taipei 105, Taiwan

[2] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2006年 / 54卷 / 02期

关键词：

D O I：

10.1016/j.jaad.2005.03.057

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Drug hypersensitivity syndrome (DHS) is an idiosyncratic and life-threatening adverse drug reaction characterized by skin rash and multiorgan involvement. In rare cases, fulminant type1 diabetes mellitus (DM) may develop after DHS. Among proposed pathogenesis, human herpesvirus 6 (HHV-6) infections may play a role in the development of DHS. We report a case of DHS associated with HHV-6 reactivation, complicated with a rare sequela of irreversible fulminant type I DM. No diabetes-related autoantibodies were detected. Early detection and intervention for this serious complication should be given in patients with DHS. Fulminant type1 DM associated with DHS is reviewed. The role of HHV-6 in DHS associated with fulminant type 1 DM is also discussed.

引用

页码：S14 / S17

页数：4

共 14 条

[1] Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction [J].