Extensive peroxynitrite activity during progressive stages of central nervous system inflammation

被引:137
作者
vanderVeen, RC [1 ]
Hinton, DR [1 ]
Incardonna, F [1 ]
Hofman, FM [1 ]
机构
[1] UNIV SO CALIF,SCH MED,DEPT PATHOL,LOS ANGELES,CA 90033
关键词
experimental autoimmune encephalomyelitis; CNS Inflammation; peroxynitrite; free radicals; immunohistochemistry;
D O I
10.1016/S0165-5728(97)00013-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nitric oxide (NO) production has been associated with disease activity in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). This free radical can be transformed by superoxide to peroxynitrite, an extremely toxic oxidant which causes lipid peroxidation. In addition, peroxynitrite nitrates tyrosine residues, resulting in nitrotyrosine, which can be identified immunohistochemically. The results of this study indicate that peroxynitrite is formed very early during EAE development, correlating with clinical disease activity. Nitrotyrosine-positive cells display a widespread distribution in brain and spinal cord during severe disease and are associated with both perivascular infiltrates and parenchymal sites. Double-staining procedures demonstrated that a subpopulation of CD11b-positive cells (macrophages/microglia) reacted with nitrotyrosine antibodies. Immunostaining for inducible NO synthase demonstrated a similar distribution as nitrotyrosine staining. These experiments indicate that peroxynitrite is formed during progressive stages of disease activity.
引用
收藏
页码:1 / 7
页数:7
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