Risk factors for Nipah virus encephalitis in Bangladesh

被引：70

作者：

Montgomery, Joel M. ^{[1
]}

Hossain, Mohamed J. ^{[2
]}

Gurley, E. ^{[2
]}

Carroll, D. S. ^{[1
]}

Croisier, A. ^{[3
]}

Bertherat, E. ^{[3
]}

Asgari, N. ^{[3
]}

Formenty, P. ^{[3
]}

Keeler, N. ^{[1
]}

Comer, J. ^{[1
]}

Bell, M. R. ^{[1
]}

Akram, K. ^{[4
]}

Molla, A. R. ^{[5
]}

Zaman, K. ^{[4
]}

Islam, Mohamed R. ^{[5
]}

Wagoner, K. ^{[1
]}

Mills, J. N. ^{[1
]}

Rollin, P. E. ^{[1
]}

Ksiazek, T. G. ^{[1
]}

Breiman, R. F. ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA USA

[2] Int Ctr Diarrheal Dis Res, Dhaka, Bangladesh

[3] WHO, CH-1211 Geneva, Switzerland

[4] WHO, Dhaka, Bangladesh

[5] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh

来源：

EMERGING INFECTIOUS DISEASES | 2008年 / 14卷 / 10期

关键词：

D O I：

10.3201/eid1410.060507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Nipah virus (NiV) is a paramyxovirus that causes severe encephalitis in humans. During January 2004, twelve patients with NiV encephalitis (NiVE) were identified in west-central Bangladesh. A case-control study was conducted to identify factors associated with NiV infection. NiVE patients from the outbreak were enrolled in a matched case-control study. Exact odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using a matched analysis. Climbing trees (83% of cases vs. 51% of controls, OR 8.2, 95% Cl 1.25-infinity) and contact with another NiVE patient (67% of cases vs. 9% of controls, OR 21.4, 95% CI 2.78-966.1) were associated with infection. We did not identify an increased risk for NiV infection among persons who had contact with a potential intermediate host. Although we cannot rule out person-to-person transmission, case-patients were likely infected from contact with fruit bats or their secretions.

引用

页码：1526 / 1532

页数：7

共 34 条

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