Synthetic strategy toward skeletal diversity via solid-supported, Otherwise unstable reactive intermediates

Solid supports lend stability: Skeletally diverse alkaloid-like compounds were obtained in only three steps from simple starting materials through a strategy based on dihydropyridine and dihydroisoquinoline intermediates supported on macrobeads (see picture). The otherwise unstable enamine double bond present in the intermediates can undergo a variety of transformations, including cycloadditions, selective reductions, and alkylations.