Adenovirus vectors for gene delivery

被引：304

作者：

Benihoud, K ^{[1
]}

Yeh, P ^{[1
]}

Perricaudet, M ^{[1
]}

机构：

[1] Inst Gustave Roussy, IGR, Rhone Poulenc Gencell, CNRS,UMR1582,Lab Vectorol & Transfert Genes, F-94805 Villejuif, France

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0958-1669(99)00007-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent endeavors in the development of adenovirus as a gene vector have focused on the modification of virus tropism, the accommodation of larger genes, and the increase in si:ability and control of transgene expression. Whereas partial or total deletions of viral genes increase the cloning capacity and partly reduce the cellular immune response, control of the humoral response, which often precludes efficient readministration, remains a challenge.

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页码：440 / 447

页数：8

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