Combinatorial codes in signaling and synergy: lessons from pituitary development

被引：55

作者：

Dasen, JS

Rosenfeld, MG

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, Dept Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Howard Hughes Med Inst, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(99)00015-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The development of the hormone-secreting cell types in the pituitary gland provides an excellent model system in which to explore the complex transcriptional mechanisms underlying the specification and maintenance of differentiated cell types in mammalian organogenesis. Pituitary development is orchestrated through the combinatorial actions of a repertoire of signaling-gradient-induced transcription factors which, on the basis of their distinct and overlapping expression patterns, and functional interactions, ultimately has led to the generation of functionally distinct cell phenotypes from a common ectodermal primordium.

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页码：566 / 574

页数：9

相关论文

共 67 条

[1] Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins [J].

Agulnick, AD ;

Taira, M ;

Breen, JJ ;

Tanaka, T ;

Dawid, IB ;

Westphal, H .

NATURE, 1996, 384 (6606) :270-272

[2] The ames dwarf gene is required for Pit-1 gene activation [J].

Andersen, B ;

Pearse, RV ;

Jenne, K ;

Sornson, M ;

Lin, SC ;

Bartke, A ;

Rosenfeld, MG .

DEVELOPMENTAL BIOLOGY, 1995, 172 (02) :495-503

[3] P-LIM, A LIM HOMEODOMAIN FACTOR, IS EXPRESSED DURING PITUITARY ORGAN AND CELL COMMITMENT AND SYNERGIZES WITH PIT-1 [J].

BACH, I ;

RHODES, SJ ;

PEARSE, RV ;

HEINZEL, T ;

GLOSS, B ;

SCULLY, KM ;

SAWCHENKO, PE ;

ROSENFELD, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2720-2724

[4] A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins [J].

Bach, I ;

Carriere, C ;

Ostendorff, HP ;

Andersen, B ;

Rosenfeld, MG .

GENES & DEVELOPMENT, 1997, 11 (11) :1370-1380

[5] DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression [J].

Bennani-Baïti, IM ;

Asa, SL ;

Song, DC ;

Iratni, R ;

Liebhaber, SA ;

Cooke, NE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) :10655-10660

[6] THE PITUITARY-SPECIFIC TRANSCRIPTION FACTOR-GHF-1 IS A HOMEOBOX-CONTAINING PROTEIN [J].

BODNER, M ;

CASTRILLO, JL ;

THEILL, LE ;

DEERINCK, T ;

ELLISMAN, M ;

KARIN, M .

CELL, 1988, 55 (03) :505-518

[7] Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression [J].

Bradford, AP ;

Wasylyk, C ;

Wasylyk, B ;

GutierrezHartmann, A .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (03) :1065-1074

[8] Cell-specific expression of the mouse glycoprotein hormone α-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells [J].

Brinkmeier, ML ;

Gordon, DF ;

Dowding, JM ;

Saunders, TL ;

Kendall, SK ;

Sarapura, VD ;

Wood, WM ;

Ridgway, EC ;

Camper, SA .

MOLECULAR ENDOCRINOLOGY, 1998, 12 (05) :622-633

[9] LOCALIZATION OF THE PANHYPOPITUITARY DWARF MUTATION (DF) ON MOUSE CHROMOSOME-11 IN AN INTERSUBSPECIFIC BACKCROSS [J].

BUCKWALTER, MS ;

KATZ, RW ;

CAMPER, SA .

GENOMICS, 1991, 10 (03) :515-526

[10] Defective retinoic acid regulation of the Pit-1 gene enhancer:: A novel mechanism of combined pituitary hormone deficiency [J].

Cohen, LE ;

Zanger, K ;

Brue, T ;

Wondisford, FE ;

Radovick, S .

MOLECULAR ENDOCRINOLOGY, 1999, 13 (03) :476-484

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