Relationship of urinary arsenic metabolites to intake estimates in residents of the Red River Delta, Vietnam

被引：51

作者：

Agusa, Tetsuro ^{[1
,2
]}

Kunito, Takashi ^{[3
]}

Minh, Tu Binh ^{[1
,4
]}

Trang, Pham Thi Kim ^{[5
]}

Iwata, Hisato ^{[1
]}

Viet, Pham Hung ^{[5
]}

Tanabe, Shinsuke ^{[1
]}

机构：

[1] Ehime Univ, CMES, Matsuyama, Ehime 7908577, Japan

[2] Shimane Univ, Fac Med, Dept Legal Med, Izumo, Shimane 6938501, Japan

[3] Shinshu Univ, Fac Sci & Engn, Dept Environm Sci, Matsumoto, Nagano 3908621, Japan

[4] City Univ Hong Kong, Dept Biol & Chem BCH, Kowloon Tong, Hong Kong, Peoples R China

[5] Hanoi Natl Univ, CETASD, Hanoi, Vietnam

来源：

ENVIRONMENTAL POLLUTION | 2009年 / 157卷 / 02期

基金：

日本学术振兴会;

关键词：

Arsenic; Groundwater; Rice; Human urine; Methylation capacity; Red River Delta; Vietnam; DRINKING-WATER; WEST-BENGAL; DIETARY-INTAKE; METHYLATION PATTERNS; REPAIR GENES; SKIN-LESIONS; GROUNDWATER; RICE; POLYMORPHISMS; CONTAMINATION;

D O I：

10.1016/j.envpol.2008.09.043

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study investigated the status of arsenic (As) exposure from groundwater and rice, and its methylation capacity in residents from the Red River Delta, Vietnam. Arsenic levels in groundwater ranged from <1.8 to 486 mu g/L Remarkably, 86% of groundwater samples exceeded WHO drinking water guideline of 10 mu g/L Also, estimated inorganic As intake from groundwater and rice were over Provisional Tolerable Weekly Intake (15 mu g/week/kg body wt.) by FAO/WHO for 92% of the residents examined. Inorganic As and its metabolite (monomethylarsonic acid and dimethylarsinic acid) concentrations in human urine were positively correlated with estimated inorganic As intake. These results suggest that residents in these areas are exposed to As through consumption of groundwater and rice, and potential health risk of As is of great concern for these people. Urinary concentration ratios of dimethylarsinic acid to monomethylarsonic acid in children were higher than those in adults, especially among men, indicating greater As methylation capacity in children. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：396 / 403

页数：8

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