Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain

被引：19

作者：

Nitta, A ^{[1
]}

Fukumitsu, H ^{[1
]}

Kataoka, H ^{[1
]}

Nomoto, H ^{[1
]}

Furukawa, S ^{[1
]}

机构：

[1] GIFU PHARMACEUT UNIV, MOL BIOL LAB, GIFU 502, JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 226卷 / 02期

关键词：

neurotrophin; brain-derived neurotrophic factor (BDNF); glucocorticoid; corticosterone; immunohistochemistry; rats;

D O I：

10.1016/S0304-3940(97)00256-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle. In the immunohistochemical study, BDNF-like immunoreactivity (LI) was observed predominantly in the nucleus of the cortical and hippocampal neurons in the brain of vehicle-treated rats. In corticosterone-treated rats, BDNF-LI was markedly reduced in the nucleus and concomitantly increased in cytoplasm. Western immunoblot study also demonstrated that corticosterone significantly reduced BDNF-LI in the nuclear fraction of the cerebral cortex and hippocampus. These results indicate that corticostrone regulates the intracellular localization of BDNF and/or its derivatives in the rat brain. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：115 / 118

页数：4

共 18 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].