Hidden powers of the mitochondria

被引：25

作者：

Alnemri, ES ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Inst, Philadelphia, PA 19107 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1038/10034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intermembrane space of mitochondria is home to several potentially lethal proteins, including pro-apoptotic caspases. The observation that caspase-9 moves from mitochondria Into the nucleus on the induction of apoptosis provides this caspase with a possible new role.

引用

页码：E40 / E42

页数：3

共 13 条

[1] Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
Cecconi, F
Alvarez-Bolado, G
Meyer, BI
Roth, KA
Gruss, P
[J]. CELL, 1998, 94 (06) : 727 - 737
[2] Differential requirement for Caspase 9 in apoptotic pathways in vivo
Hakem, R
Hakem, A
Duncan, GS
Henderson, JT
Woo, M
Soengas, MS
Elia, A
de la Pompa, JL
Kagi, D
Khoo, W
Potter, J
Yoshida, R
Kaufman, SA
Lowe, SW
Penninger, JM
Mak, TW
[J]. CELL, 1998, 94 (03) : 339 - 352
[3] Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
Krajewski, S
Krajewska, M
Ellerby, LM
Welsh, K
Xie, ZH
Deveraux, QL
Salvesen, GS
Bredesen, DE
Rosenthal, RE
Fiskum, G
Reed, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) : 5752 - 5757
[4] Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking Caspase 9
Kuida, K
Haydar, TF
Kuan, CY
Gu, Y
Taya, C
Karasuyama, H
Su, MSS
Rakic, P
Flavell, RA
[J]. CELL, 1998, 94 (03) : 325 - 337
[5] Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Li, HL
Zhu, H
Xu, CJ
Yuan, JY
[J]. CELL, 1998, 94 (04) : 491 - 501
[6] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
Li, P
Nijhawan, D
Budihardjo, I
Srinivasula, SM
Ahmad, M
Alnemri, ES
Wang, XD
[J]. CELL, 1997, 91 (04) : 479 - 489
[7] Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
Luo, X
Budihardjo, I
Zou, H
Slaughter, C
Wang, XD
[J]. CELL, 1998, 94 (04) : 481 - 490
[8] SALEH A, IN PRESS J BIOL CEHM
[9] Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
Soengas, MS
Alarcón, RM
Yoshida, H
Giaccia, AJ
Hakem, R
Mak, TW
Lowe, SW
[J]. SCIENCE, 1999, 284 (5411) : 156 - 159
[10] Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
Srinivasula, SM
Ahmad, M
Fernandes-Alnemri, T
Alnemri, ES
[J]. MOLECULAR CELL, 1998, 1 (07) : 949 - 957

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