New pyrazole containing bicarboxylic α-amino acids:: mimics of the cis amide bond

被引：19

作者：

De Luca, L ^{[1
]}

Falorni, M ^{[1
]}

Giacomelli, G ^{[1
]}

Porcheddu, A ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

关键词：

amino acids; amino acid derivatives; cycloadditions; pyrazoles;

D O I：

10.1016/S0040-4039(99)01847-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel optically active oc-amino acids, containing a pyrazole ring, which can be regarded as building blocks for peptidomimetics, have been prepared starting from readily available oc-amino acids. The synthetic strategy employed allows the regio- and stereoselective preparation of 1,3- or 1,5-substituted pyrazolyl rings. The pyrazole containing peptidomimetics can be considered as analogues of peptides with a cis amide bond. (C) 1999 Elsevier Science Ltd, All rights reserved.

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收藏

页码：8701 / 8704

页数：4

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