Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

被引：27

作者：

Duberley, RM

Johnson, IP

Anand, P

Leigh, PN

Cairns, NJ

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT ANAT & DEV BIOL,LONDON NW3 2PF,ENGLAND

[2] INST PSYCHIAT,DEPT NEUROL,LONDON SE5 8AF,ENGLAND

[3] INST PSYCHIAT,DEPT NEUROPATHOL,LONDON SE5 8AF,ENGLAND

[4] ST BARTHOLOMEWS & ROYAL LONDON HOSP,SCH MED & DENT,DEPT NEUROL,LONDON E1 1BB,ENGLAND

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 148卷 / 01期

基金：

英国医学研究理事会;

关键词：

amyotrophic lateral sclerosis; neurotrophin-3; Trk C; motoneurones; immunocytochemistry; in situ hybridisation;

D O I：

10.1016/S0022-510X(96)00312-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have demonstrated neurotrophin-3 (NT-3) like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS. (C) 1997 Elsevier Science B.V.

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页码：33 / 40

页数：8

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