Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis

被引:27
作者
Duberley, RM
Johnson, IP
Anand, P
Leigh, PN
Cairns, NJ
机构
[1] ROYAL FREE HOSP,SCH MED,DEPT ANAT & DEV BIOL,LONDON NW3 2PF,ENGLAND
[2] INST PSYCHIAT,DEPT NEUROL,LONDON SE5 8AF,ENGLAND
[3] INST PSYCHIAT,DEPT NEUROPATHOL,LONDON SE5 8AF,ENGLAND
[4] ST BARTHOLOMEWS & ROYAL LONDON HOSP,SCH MED & DENT,DEPT NEUROL,LONDON E1 1BB,ENGLAND
基金
英国医学研究理事会;
关键词
amyotrophic lateral sclerosis; neurotrophin-3; Trk C; motoneurones; immunocytochemistry; in situ hybridisation;
D O I
10.1016/S0022-510X(96)00312-7
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We have demonstrated neurotrophin-3 (NT-3) like immunoreactivity and tyrosine kinase C (Trk C) receptor expression in motoneurones in postmortem amyotrophic lateral sclerosis (ALS) and control human spinal cord sections. We report that NT-3-like immunoreactivity in motoneurones is decreased in ALS when compared to control tissue. Trk C is expressed in low abundance in both control and ALS motoneurones. These findings are of importance in developing therapeutic strategies for ALS. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:33 / 40
页数:8
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