Polymorphonuclear granulocyte stimulation by cellulose-based hemodialysis membranes

被引:14
作者
Körmöczi, GF
Rosenkranz, AR
Zlabinger, GJ
机构
[1] Univ Vienna, Inst Immunol, Div Nephrol & Dialysis, A-1090 Vienna, Austria
[2] Univ Vienna, Dept Internal Med 3, Div Nephrol & Dialysis, A-1090 Vienna, Austria
关键词
hemodialysis; cellulose-based membranes; granulocyte; oxidative burst; adhesion molecules; complement;
D O I
10.1515/CCLM.1999.058
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Hemodialyis with cellulose-based membranes is associated with an array of adverse reactions, including leukopenia, pulmonary sequestration and dysfunction of leukocytes. Activation of the alternative pathway of complement due to direct contact of plasma with dialysis membrane is considered to be responsible for the induction of these side effects. In recent years, evidence has accumulated that other neutrophil effector functions such as reactive oxygen intermediate production play an important role as well. Here! the importance of burst formation in cooperation with other in flammatory effector functions in the mechanisms of hemodialysis-related adverse effects will be discussed.
引用
收藏
页码:351 / 355
页数:5
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