Antibodies reactive with the cryptococcal capsular polysaccharide glucuronoxylomannan are present in sera from children with and without human immunodeficiency virus infection

被引:64
作者
Abadi, J
Pirofski, LA
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Div Infect Dis, Dept Pediat, Bronx, NY 10461 USA
[2] Yeshiva Univ Albert Einstein Coll Med, Div Infect Dis, Dept Med, Bronx, NY 10461 USA
[3] Yeshiva Univ Albert Einstein Coll Med, Div Infect Dis, Dept Microbiol & Immunol, Bronx, NY 10461 USA
关键词
D O I
10.1086/314953
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antibodies reactive with the cryptococcal polysaccharide glucuronoxylomannan (GXM) are present in sera from both human immunodeficiency virus (HIV)-uninfected and -infected adults. However, the prevalence of these antibodies in US children is unknown, An antigen-capture ELISA was used to determine the presence, serotype specificity, isotype, and IgG subclass distribution of antibodies to GXM in sera from 27 HIV-uninfected and 34 HIV-infected children. The children were of similar age and socioeconomic background. IgG and IgM to GXM were present in sera from all children, although HIV-uninfected children had significantly higher titers, HIV-uninfected children had IgG1 and IgG2 to GXM and significantly greater IgG2 than in HIV-infected children. These findings of type-specific antibodies to GXM in early childhood suggest that exposure to or subclinical infection with Cryptococcus neoformans may be an early childhood event.
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收藏
页码:915 / 919
页数:5
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