Unraveling the therapeutic effects of mesenchymal stem cells in asthma

被引：29

作者：

Mirershadi, Fatemeh ^{[1
,2
]}

Ahmadi, Mahdi ^{[1
,3
]}

Rezabakhsh, Aysa ^{[4
]}

Rajabi, Hadi ^{[5
,6
]}

Rahbarghazi, Reza ^{[7
,8
]}

Keyhanmanesh, Rana ^{[1
,3
,7
]}

机构：

[1] Tabriz Univ Med Sci, Dept Physiol, Fac Med, Daneshgah St, Tabriz 5166614766, Iran

[2] Islamic Azad Univ, Ardabil Branch, Dept Physiol, Ardebil, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran

[5] Koc Univ, Koc Univ Res Ctr Translat Med KUTTAM, Sch Med, Istanbul, Turkey

[6] Koc Univ, Dept Pulm Med, Sch Med, Istanbul, Turkey

[7] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[8] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Appl Cell Sci, Daneshgah St, Tabriz 5154853431, Iran

来源：

STEM CELL RESEARCH & THERAPY | 2020年 / 11卷 / 01期

关键词：

Stem cells; Asthma; Regeneration; Cellular and molecular mechanisms; ALLERGIC AIRWAY INFLAMMATION; HUMAN BONE-MARROW; STROMAL CELLS; MURINE MODEL; MOUSE MODEL; C-KIT; MITOCHONDRIAL TRANSFER; CONDITIONED MEDIA; ANIMAL-MODELS; ADIPOSE;

D O I：

10.1186/s13287-020-01921-2

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases' alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms.

引用

页数：12

共 116 条

[1]

Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma [J].