Activation of NF-κB by r5 and x4 human immunodeficiency virus type 1 induces macrophage inflammatory protein 1α and tumor necrosis factor alpha in macrophages

被引：22

作者：

Choe, W ^{[1
]}

Volsky, DJ ^{[1
]}

Potash, MJ ^{[1
]}

机构：

[1] Columbia Univ, St Lukes Roosevelt Hosp Ctr, Div Mol Virol, New York, NY 10019 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 10期

关键词：

D O I：

10.1128/JVI.76.10.5274-5277.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

NF-kappaB is a transcriptional activator that often regulates inflammatory responses. We demonstrate that human immunodeficiency virus type I activates nuclear localization of NF-kappaB in macrophages in a manner dependent upon virus strain but independent of virus replication. Through the use of an inhibitor, NF-kappaB activation was found to be responsible for the cytokine and chemokine induction that we recently reported.

引用

页码：5274 / 5277

页数：4

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