Targeting Hepatic Glucokinase in Type 2 Diabetes Weighing the Benefits and Risks

被引：54

作者：

Agius, Loranne ^{[1
]}

机构：

[1] Univ Newcastle, Sch Med, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England

来源：

DIABETES | 2009年 / 58卷 / 01期

关键词：

REGULATORY PROTEIN; GLUCOSE-HOMEOSTASIS; GLYCOGEN-METABOLISM; TRIGLYCERIDE LEVELS; FASTING GLUCOSE; FATTY RATS; LIVER; ACTIVATORS; DEFECT; LOCI;

D O I：

10.2337/db08-1470

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：18 / 20

页数：3

共 20 条

[1] Glucokinase and molecular aspects of liver glycogen metabolism [J].

Agius, Loranne .

BIOCHEMICAL JOURNAL, 2008, 414 :1-18

[2] New hepatic targets for glycaemic control in diabetes [J].

Agius, Loranne .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 21 (04) :587-605

[3] Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism - Evidence for a defect in haptic glucokinase activity [J].

Basu, A ;

Basu, R ;

Shah, P ;

Vella, A ;

Johnson, CM ;

Nair, KS ;

Jensen, MD ;

Schwenk, WF ;

Rizza, RA .

DIABETES, 2000, 49 (02) :272-283

[4] LIVER GLUCOKINASE - DECREASED ACTIVITY IN PATIENTS WITH TYPE-II DIABETES [J].

CARO, JF ;

TRIESTER, S ;

PATEL, VK ;

TAPSCOTT, EB ;

FRAZIER, NL ;

DOHM, GL .

HORMONE AND METABOLIC RESEARCH, 1995, 27 (01) :19-22

[5] Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats [J].

Chirieac, DV ;

Collins, HL ;

Cianci, J ;

Sparks, JD ;

Sparks, CE .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 287 (01) :E42-E49

[6] Glucokinase activators in diabetes management [J].

Coghlan, Matthew ;

Leighton, Brendan .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2008, 17 (02) :145-167

[7] Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes [J].

Krssak, M ;

Brehm, A ;

Bernroider, E ;

Anderwald, C ;

Nowotny, P ;

Man, CD ;

Dalla Man, C ;

Cline, GW ;

Shulman, GI ;

Waldhäusl, W ;

Roden, M .

DIABETES, 2004, 53 (12) :3048-3056

[8]

Matschinsky FM, 2006, DIABETES, V55, P1

[9] Regulation of endogenous glucose production by glucose per se is impaired in Type 2 diabetes mellitus [J].

Mevorach, M ;

Giacca, A ;

Aharon, Y ;

Hawkins, M ;

Shamoon, H ;

Rossetti, L .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (04) :744-753

[10] Metabolic impact of glucokinase overexpression in liver -: Lowering of blood glucose in fed rats is accompanied by hyperlipidemia [J].

O'Doherty, RM ;

Lehman, DL ;

Télémaque-Potts, S ;

Newgard, CB .

DIABETES, 1999, 48 (10) :2022-2027

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