Long-Term Impact of Infection on the Preterm Neonate

被引：39

作者：

Adams-Chapman, Ira ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pediat, Div Neonatol,Dev Progress Clin, Atlanta, GA 30303 USA

来源：

SEMINARS IN PERINATOLOGY | 2012年 / 36卷 / 06期

关键词：

neonate; infection; neurodevelopmental outcome; inflammation; cytokines; BIRTH-WEIGHT INFANTS; CHRONIC LUNG-DISEASE; WHITE-MATTER LESIONS; BRONCHOPULMONARY DYSPLASIA; INTRAUTERINE INFECTION; CEREBRAL-PALSY; PERIVENTRICULAR LEUKOMALACIA; INFLAMMATORY MEDIATORS; PREMATURE-INFANTS; NATIONAL COHORT;

D O I：

10.1053/j.semperi.2012.06.009

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Prematurely born infants are at increased risk for infection throughout their hospitalization. Various developmentally regulated processes involving the central nervous and respiratory systems may be disrupted by the proinflammatory state associated with infection, resulting in an increased risk for death, chronic lung disease, and adverse neurodevelopmental outcome. This review summarizes the current understanding of the long-term impact of infection and/or inflammation in preterm infants, including the risks associated with perinatal infection, early-onset sepsis, late-onset sepsis, and necrotizing enterocolitis. Semin Perinatol 36:462-470 (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：462 / 470

页数：9

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