Factor Xa - a promising target for drug development

被引:43
作者
Kaiser, B [1 ]
机构
[1] Univ Jena, Ctr Vasc Biol & Med Erfurt, D-99089 Erfurt, Germany
关键词
D O I
10.1007/s00018-002-8415-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:189 / 192
页数:4
相关论文
共 40 条
[21]  
LASSEN MR, 2001, THROMB HAEMOST S, pOC45
[22]   THE COAGULATION EXPLOSION [J].
MANN, KG ;
KALAFATIS, M .
CEREBROVASCULAR DISEASES, 1995, 5 (02) :93-97
[23]   Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers [J].
Murayama, N ;
Tanaka, M ;
Kunitada, S ;
Yamada, H ;
Inoue, T ;
Terada, Y ;
Fujita, M ;
Ikeda, Y .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1999, 66 (03) :258-264
[24]   Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors [J].
Nar, H ;
Bauer, M ;
Schmid, A ;
Stassen, JM ;
Wienen, W ;
Priepke, HWM ;
Kauffmann, IK ;
Ries, UJ ;
Hauel, NH .
STRUCTURE, 2001, 9 (01) :29-37
[25]  
OLSON ST, 1992, J BIOL CHEM, V267, P12528
[26]   Synthesis and pharmacological properties of a close analogue of an antithrombotic pentasaccharide (SR 90107A ORG 31540) [J].
Petitou, M ;
Duchaussoy, P ;
Jaurand, G ;
Gourvenec, F ;
Lederman, I ;
Strassel, JM ;
Barzu, T ;
Crepon, B ;
Herault, JP ;
Lormeau, JC ;
Bernat, A ;
Herbert, JM .
JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (11) :1600-1607
[27]   Recent advances in clinical trials of the direct and indirect selective Factor Xa inhibitors [J].
Porcari, AR ;
Chi, L ;
Leadley, R .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2000, 9 (07) :1595-1600
[28]   ROLE OF THROMBIN COMPARED WITH FACTOR XA IN THE PROCOAGULANT ACTIVITY OF WHOLE-BLOOD CLOTS [J].
PRAGER, NA ;
ABENDSCHEIN, DR ;
MCKENZIE, CR ;
EISENBERG, PR .
CIRCULATION, 1995, 92 (04) :962-967
[29]   Perspectives on factor Xa inhibition [J].
Rai, R ;
Sprengeler, PA ;
Elrod, KC ;
Young, WB .
CURRENT MEDICINAL CHEMISTRY, 2001, 8 (02) :101-119
[30]   Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1 [J].
Riewald, M ;
Kravchenko, VV ;
Petrovan, RJ ;
O'Brien, PJ ;
Brass, LF ;
Ulevitch, RJ ;
Ruf, W .
BLOOD, 2001, 97 (10) :3109-3116