ESR study of radical processes in irradiated DNA: The effect of the complexation with cis-dichloro diamino Pt(II)

被引：2

作者：

Faucitano, A ^{[1
]}

Buttafava, A ^{[1
]}

Magnaghi, S ^{[1
]}

PedraliNoy, G ^{[1
]}

机构：

[1] CNR,LI GBE,PAVIA,ITALY

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 1996年 / 22卷 / 04期

关键词：

D O I：

10.1163/156856796X00034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The room temperature esr spectra of irradiated neat duplex hydrated, dehydrated and thermally denaturated DNA are interpreted in terms of the radicals formed by protonation of the thymine and cytosine anion radicals, by deprotonation of the guanine cation radicals, by addition of OH radicals at C8 of guanine and by loss of a methyl hydrogen from thymine. The complexation of DNA with cis-dichlorodiamino Pt(II) causes a drastic alteration of the radical distribution interpreted in terms of electron scavenging by the Pt(II) complex, a partial inhibition of the radical-cation chemistry of guanine, and enhancement of the reactivity of thymine toward hydrogen abstractions.

引用

页码：325 / 342

页数：18

共 31 条

[1] PT-195 NMR KINETIC AND MECHANISTIC STUDIES OF CIS-DIAMMINEDICHLOROPLATINUM AND TRANS-DIAMMINEDICHLOROPLATINUM(II) BINDING TO DNA [J].