The formation of an organic coat and the release of corrosion microparticles from metallic magnesium implants

被引：47

作者：

Badar, Muhammad ^{[1
]}

Luensdorf, Heinrich ^{[1
]}

Evertz, Florian ^{[2
]}

Rahim, Muhammad Imran ^{[1
]}

Glasmacher, Birgit ^{[2
]}

Hauser, Hansjoerg ^{[1
]}

Mueller, Peter P. ^{[1
]}

机构：

[1] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany

[2] Leibniz Univ Hannover, Inst Multiphase Proc, D-30167 Hannover, Germany

来源：

ACTA BIOMATERIALIA | 2013年 / 9卷 / 07期

关键词：

Animal model; Biocompatibility; Biodegradation; In vivo test; Magnesium; IN-VIVO CORROSION; SIMULATED BODY-FLUIDS; BIODEGRADABLE MAGNESIUM; BIOABSORBABLE STENTS; DEGRADATION BEHAVIOR; PURE MAGNESIUM; ALLOY; VITRO; BIOMATERIALS; MODEL;

D O I：

10.1016/j.actbio.2013.03.012

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Magnesium alloys have been proposed as prospective degradable implant materials. To elucidate the complex interactions between the corroding implants and the tissue, magnesium implants were analyzed in a mouse model and the response was compared to that induced by Ti and by the resorbable polymer polyglactin, respectively. One month after implantation, distinct traces of corrosion were apparent but the magnesium implants were still intact, whereas resorbable polymeric wound suture implants were already fragmented. Analysis of magnesium implants 2 weeks after implantation by energy-dispersive X-ray spectroscopy indicated that magnesium, oxygen, calcium and phosphate were present at the implant surface. One month after implantation, the element composition of the outermost layer of the implant was indicative of tissue without detectable levels of magnesium, indicating a protective barrier function of this organic layer. In agreement with this notion, gene expression patterns in the surrounding tissue were highly similar for all implant materials investigated. However, high-resolution imaging using energy-filtered transmission electron microscopy revealed magnesium-containing microparticles in the tissue in the proximity of the implant. The release of such corrosion particles may contribute to the accumulation of calcium phosphate in the nearby tissue and to bone conductive activities of magnesium implants. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：7580 / 7589

页数：10

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