Genomic imprinting in mammals - an interplay between chromatin and DNA methylation?

被引：105

作者：

Feil, R ^{[1
]}

Khosla, S ^{[1
]}

机构：

[1] Babraham Inst, Programme Dev Genet, Cambridge CB2 4AT, England

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 11期

关键词：

D O I：

10.1016/S0168-9525(99)01822-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Most imprinted loci have key regulatory elements that are methylated on only one of the parental chromosomes. For several of these 'differentially methylated regions', recent studies establish that the unmethylated chromosome has a specialized chromatin organization that is characterized by nuclease hypersensitivity. The novel data raise the question of whether specific proteins and associated chromatin features regulate the allele-specificity of DNA methylation at these imprinting control elements.

引用

页码：431 / 435

页数：5

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