A new entry for the synthesis of N-acyl-N′-substituted guanidines

被引:26
作者
Shinada, T [1 ]
Umezawa, T [1 ]
Ando, T [1 ]
Kozuma, H [1 ]
Ohfune, Y [1 ]
机构
[1] Osaka City Univ, Grad Sch Sci, Osaka 5588585, Japan
基金
日本学术振兴会;
关键词
thiourea; guanidine; condensation reaction; EDCI; HMDS;
D O I
10.1016/j.tetlet.2006.01.065
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient synthesis of N-acyl-N'-substituted guanidines by condensation reaction of thiourea and (Me3Si)(2)NH in the presence of EDCI is described. Various guanidines were synthesized in a simple manner. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1945 / 1947
页数:3
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