Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats

被引：6

作者：

Adamovic, Tatjana ^{[1
]}

McAllister, Donna ^{[2
]}

Rowe, J. Jordi ^{[3
]}

Wang, Tao ^{[4
]}

Jacob, Howard J. ^{[1
,5
,6
]}

Sugg, Sonia L. ^{[7
]}

机构：

[1] Med Coll Wisconsin, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA

[3] Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA

[4] Med Coll Wisconsin, Dept Populat Hlth, Div Biostat, Madison, WI USA

[5] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

[6] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

[7] Univ Iowa, Dept Surg, Iowa City, IA 52242 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 2008年 / 186卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2008.05.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Identification of novel breast cancer susceptibility and resistance genes in genetically diverse human populations is challenging, and so inbred rats have been used to identify novel mammary cancer susceptibility quantitative trait loci (QTLs) with conventional mapping approaches. An alternative approach for QTL mapping is to use chromosome substitution (consomic) rat strains, which has the advantage of rapid generation of congenic from consomic animals. Using a novel rat strain pair, SS and BN, we identified rat mammary cancer QTLs in one of two consomic rat strains tested. Female rats of inbred parental (SS and BN) and two consomic (SS-10(BN) and SS-12(BN)) strains were treated with 7,12-dimethylbenz[a]anthracene orally. The phenotypes of tumor incidence, latency, and multiplicity were evaluated. SS rats were highly susceptible to mammary adenocarcinoma development, whereas BN rats were completely resistant. Statistical comparison of the phenotypes between the susceptible parental and the two consomic strains identified QTLs residing within chromosome 10 controlling mammary tumor latency and multiplicity. The study shows that SS-BN consomic rat strains can be used to map mammary tumor QTLs. This novel approach should accelerate positional cloning of mammary cancer susceptibility and resistant genes in the rat and the identification of homologous genes in humans. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：41 / 48

页数：8

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