Stereoselective synthesis of α,α-disubstituted amines by a sequential nucleophilic addition to O-protected cyanohydrins

被引：18

作者：

Charette, AB ^{[1
]}

Gagnon, A ^{[1
]}

机构：

[1] Univ Montreal, Dept Chim, Montreal, PQ H3C 3J7, Canada

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0957-4166(99)00201-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The first enantioselective double nucleophilic addition reaction to O-protected cyanohydrin was achieved in 71% yield and 82:18 enantiomeric ratio by using a bis(BINOL)titanium Lewis acid complex. New (4S,5S)-2,2-dialkyl-4,5-bis(hydroxymethyl)-1,3-dioxolane titanium complexes were synthesized and they displayed good levels of enantioselection in the nucleophilic addition reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1961 / 1968

页数：8

共 36 条

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