Role of complement in host-microbe homeostasis of the periodontium

被引：62

作者：

Hajishengallis, George ^{[1
]}

Abe, Toshiharu ^{[1
]}

Maekawa, Tomoki ^{[1
]}

Hajishengallis, Evlambia ^{[2
]}

Lambris, John D. ^{[3
]}

机构：

[1] Univ Penn, Sch Dent Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Dent Med, Dept Restorat & Prevent Sci, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Dent Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

SEMINARS IN IMMUNOLOGY | 2013年 / 25卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Complement; C5a receptor; Periodontitis; Dysbiosis; Porphyromonas gingivalis; GINGIVAL CREVICULAR FLUID; PORPHYROMONAS-GINGIVALIS; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; PREVOTELLA-INTERMEDIA; CYSTEINE PROTEINASES; CLEAVAGE PRODUCTS; GENE-EXPRESSION; COMPONENTS C3; ACTIVATION; HEALTH;

D O I：

10.1016/j.smim.2013.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement plays a key role in immunity and inflammation through direct effects on immune cells or via crosstalk and regulation of other host signaling pathways. Deregulation of these finely balanced complement activities can link infection to inflammatory tissue damage. Periodontitis is a polymicrobial community-induced chronic inflammatory disease that can destroy the tooth-supporting tissues. In this review, we summarize and discuss evidence that complement is involved in the dysbiotic transformation of the periodontal microbiota and in the inflammatory process that leads to the destruction of periodontal bone. Recent insights into the mechanisms of complement involvement in periodontitis have additionally provided likely targets for therapeutic intervention against this oral disease. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：65 / 72

页数：8

共 128 条

[1] Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist [J].

Abe, Toshiharu ;

Hosur, Kavita B. ;

Hajishengallis, Evlambia ;

Reis, Edimara S. ;

Ricklin, Daniel ;

Lambris, John D. ;

Hajishengallis, George .

JOURNAL OF IMMUNOLOGY, 2012, 189 (11) :5442-5448

[2] Classifying periodontal diseases - a long-standing dilemma [J].

Armitage, GC .

PERIODONTOLOGY 2000, 2002, 30 :9-23

[3] Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans [J].

Asakawa, R ;

Komatsuzawa, H ;

Kawai, T ;

Yamada, S ;

Goncalves, RB ;

Izumi, S ;

Fujiwara, T ;

Nakano, Y ;

Suzuki, N ;

Uchida, Y ;

Ouhara, K ;

Shiba, H ;

Taubman, MA ;

Kurihara, H ;

Sugai, M .

MOLECULAR MICROBIOLOGY, 2003, 50 (04) :1125-1139

[4] COMPLEMENT FACTORS IN GINGIVAL CREVICE MATERIAL FROM HEALTHY AND INFLAMED GINGIVA IN HUMANS [J].

ATTSTROM, R ;

LAUREL, AB ;

LAHSSON, U ;

SJOHOLM, A .

JOURNAL OF PERIODONTAL RESEARCH, 1975, 10 (01) :19-27

[5] Oral biofilm-associated diseases: trends and implications for quality of life, systemic health and expenditures [J].

Beikler, Thomas ;

Flemmig, Thomas F. .

PERIODONTOLOGY 2000, 2011, 55 :87-103

[6] Gene expression in periodontal tissues following treatment [J].

Beikler, Thomas ;

Peters, Ulrike ;

Prior, Karola ;

Eisenacher, Martin ;

Flemmig, Thomas F. .

BMC MEDICAL GENOMICS, 2008, 1 (1)

[7] GENERATION OF SIGNALS ACTIVATING NEUTROPHIL FUNCTIONS BY LEUKOCYTE INTEGRINS - LFA-1 AND GP150/95, BUT NOT CR3, ARE ABLE TO STIMULATE THE RESPIRATORY BURST OF HUMAN NEUTROPHILS [J].

BERTON, G ;

LAUDANNA, C ;

SORIO, C ;

ROSSI, F .

JOURNAL OF CELL BIOLOGY, 1992, 116 (04) :1007-1017

[8] Complement evasion strategies of pathogens-Acquisition of inhibitors and beyond [J].

Blom, Anna M. ;

Hallstrom, Teresia ;

Riesbeck, Kristian .

MOLECULAR IMMUNOLOGY, 2009, 46 (14) :2808-2817

[9] THE INTERACTION OF SALIVARY SECRETIONS WITH THE HUMAN-COMPLEMENT SYSTEM - A MODEL FOR THE STUDY OF HOST DEFENSE SYSTEMS ON INFLAMED MUCOSAL SURFACES [J].

BOACKLE, RJ .

CRITICAL REVIEWS IN ORAL BIOLOGY AND MEDICINE, 1991, 2 (03) :355-367

[10] Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats [J].

Breivik, T. ;

Gundersen, Y. ;

Gjermo, P. ;

Taylor, S. M. ;

Woodruff, T. M. ;

Opstad, P. K. .

JOURNAL OF PERIODONTAL RESEARCH, 2011, 46 (06) :643-647

← 1 2 3 4 5 6 7 8 9 10 →