VHS domain - a longshoreman of vesicle lines

被引：60

作者：

Lohi, O

Poussu, A

Mao, YX

Quiocho, F

Lehto, VP ^{[1
]}

机构：

[1] Oulu Univ, Dept Pathol, FIN-90014 Oulu, Finland

[2] Tampere Univ, Dept Pediat, FIN-33101 Tampere, Finland

[3] Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA

[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[5] Univ Helsinki, Dept Pathol, FIN-00014 Helsinki, Finland

来源：

FEBS LETTERS | 2002年 / 513卷 / 01期

关键词：

GGA; signaling; vesicular trafficking; VHS domain;

D O I：

10.1016/S0014-5793(01)03287-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The VHS (Vps-27, Firs and STAM) domain is a 140 residue long domain present in the very NH2-terininus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：19 / 23

页数：5

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