Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene

被引：68

作者：

Kai, M ^{[1
]}

Matsuoka, M ^{[1
]}

Nakata, N ^{[1
]}

Maeda, S ^{[1
]}

Gidoh, M ^{[1
]}

Maeda, Y ^{[1
]}

Hashimoto, K ^{[1
]}

Kobayashi, K ^{[1
]}

Kashiwabara, Y ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Leprosy Res Ctr, Higashimurayama, Tokyo 1890002, Japan

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 177卷 / 02期

关键词：

chemotherapy; leprosy; genetic mutation; drug resistance;

D O I：

10.1111/j.1574-6968.1999.tb13737.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleo tide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：231 / 235

页数：5

共 20 条

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