Drug delivery with carbon nanotubes for in vivo cancer treatment

被引：1025

作者：

Liu, Zhuang ^{[1
]}

Chen, Kai ^{[2
]}

Davis, Corrine ^{[3
]}

Sherlock, Sarah ^{[1
]}

Cao, Qizhen ^{[2
]}

Chen, Xiaoyuan ^{[2
]}

Dai, Hongjie ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Mol Imaging Program Stanford, Dept Radiol,Biophys & BioX Program, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Comparat Med, Stanford, CA 94305 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 16期

关键词：

D O I：

10.1158/0008-5472.CAN-08-1468

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemically functionalized single-walled carbon nanotubes (SWNT) have shown promise in tumor-targeted accumulation in mice and exhibit biocompatibility, excretion, and little toxicity. Here, we show in vivo SWNT drug delivery for tumor suppression in mice. We conjugate paclitaxel (PTX), a widely used cancer chemotherapy drug, to branched polyethylene glycol chains on SWNTs via a cleavable ester bond to obtain a water-soluble SWNT-PTX conjugate. SWNT-PTX affords higher efficacy in suppressing tumor growth than clinical Taxol in a murine 4T1 breast cancer model, owing to prolonged blood circulation and 10-fold higher tumor PTX uptake by SWNT delivery likely through enhanced permeability and retention. Drug molecules carried into the reticuloendothelial. path-system are released from SWNTs and excreted via biliary way without causing obvious toxic effects to normal organs. Thus, nanotube drug delivery, is promising for high treatment efficacy and minimum side effects for future cancer therapy with low drug doses.

引用

页码：6652 / 6660

页数：9

共 48 条

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