Advancing Treatment for Metastatic Bone Cancer: Consensus Recommendations from the Second Cambridge Conference

被引：47

作者：

Coleman, Robert E. ^{[1
]}

Guise, Theresa A. ^{[3
]}

Lipton, Allan ^{[4
]}

Roodman, G. David ^{[5
]}

Berenson, James R. ^{[6
]}

Body, Jean-Jacques ^{[7
]}

Boyce, Brendan F. ^{[8
]}

Calvi, Laura M. ^{[8
]}

Hadji, Peyman ^{[9
]}

McCloskey, Eugene V. ^{[2
]}

Saad, Fred ^{[10
]}

Smith, Matthew R. ^{[11
]}

Suva, Larry J. ^{[12
]}

Taichman, Russell S. ^{[13
]}

Vessella, Robert L. ^{[14
]}

Weilbaecher, Katherine N. ^{[15
]}

机构：

[1] Univ Sheffield, Canc Res Ctr, Weston Pk Hosp, Acad Unit Clin Oncol, Sheffield S10 2SJ, S Yorkshire, England

[2] Univ Sheffield, Metab Bone Ctr, Sheffield S10 2SJ, S Yorkshire, England

[3] Univ Virginia, Dept Internal Med, Div Endocrinol, Charlottesville, VA USA

[4] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Med & Oncol, Hershey, PA 17033 USA

[5] Vet Adm Pittsburgh Healthcare Syst, Dept Med, Pittsburgh, PA USA

[6] Inst Myeloma & Bone Canc Res, West Hollywood, CA USA

[7] Univ Libre Bruxelles, CHU Brugmann, Brussels, Belgium

[8] Univ Rochester, Sch Med & Dent, Div Endocrinol Metab, New York, NY USA

[9] Univ Hosp Giessen & Marburg GmbH, Dept Endocrinol, Marburg, Germany

[10] Univ Montreal, Hop Notre Dame, Ctr Hosp, Dept Urol Oncol, Montreal, PQ, Canada

[11] Massachusetts Gen Hosp, Ctr Canc, Dept Genitourinary Med Oncol, Boston, MA USA

[12] Univ Arkansas Med Sci, Ctr Orthopaed Res, Little Rock, AR 72205 USA

[13] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA

[14] Univ Washington, Seattle, WA 98195 USA

[15] Washington Univ, Sch Med, Div Mol Oncol, St Louis, MO USA

来源：

CLINICAL CANCER RESEARCH | 2008年 / 14卷 / 20期

关键词：

D O I：

10.1158/1078-0432.CCR-08-1572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose: Summarize current knowledge, critical gaps in knowledge, and recommendations to advance the field of metastatic bone cancer. Experimental Design: A multidisciplinary consensus conference was convened to review recent progress in basic and clinical research, assess critical gaps in current knowledge, and prioritize recommendations to advance research in the next 5 years. The program addressed three principal topics: biology of metastasis, preserving normal bone health, and optimizing bone-targeted therapies. Results: A variety of specific recommendations were identified as important to advance research and clinical care over the next 5 years. Conclusions: Priorities for research in bone biology include characterizing components of the stem cell niche in bone, developing oncogenic immunocompetent animal models of bone metastasis, and investigating the unique contribution of the bone microenvironment to tumor growth and dormancy. Priorities for research in preserving normal bone health include developing methods to measure and characterize disseminating tumor cells, assessing outcomes from the major prevention trials currently in progress, and improving methodologies to assess risks and benefits of treatment. Priorities for optimizing bone-targeted therapies include advancing studies of serum proteomics and genomics to reliably identify patients who will develop bone metastases, enhancing imaging for early detection of bone metastases and early response evaluation, and developing new tests to evaluate response to bone-directed treatments.

引用

页码：6387 / 6395

页数：9

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