Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines

被引：403

作者：

Birchler, James A. ^{[1
]}

Veitia, Reiner A. ^{[2
,3
]}

机构：

[1] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA

[2] Ctr Natl Rech Sci, Inst Jacques Monod, Unite Mixte Rech 7592, F-75013 Paris, France

[3] Univ Paris Diderot, Unite Format & Rech Sci Vivant, F-75013 Paris, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 37期

基金：

美国国家卫生研究院;

关键词：

COPY-NUMBER VARIATION; WHOLE-GENOME; CHROMOSOMAL DUPLICATION; EXPRESSION EVOLUTION; SEGMENTAL ANEUPLOIDY; TRAGOPOGON-MISCELLUS; ENZYME-ACTIVITIES; DOWN-SYNDROME; FRUIT SIZE; DROSOPHILA;

D O I：

10.1073/pnas.1207726109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance effects are hypothesized to result from stoichiometric differences among members of macromolecular complexes, the interactome, and signaling pathways. The implications of gene balance are discussed.

引用

页码：14746 / 14753

页数：8

共 137 条

[1] Grass MicroRNA Gene Paleohistory Unveils New Insights into Gene Dosage Balance in Subgenome Partitioning after Whole-Genome Duplication [J].

Abrouk, Michael ;

Zhang, Rongzhi ;

Murat, Florent ;

Li, Aili ;

Pont, Caroline ;

Mao, Long ;

Salse, Jerome .

PLANT CELL, 2012, 24 (05) :1776-1792

[2] Hundreds of variants clustered in genomic loci and biological pathways affect human height [J].

Allen, Hana Lango ;

Estrada, Karol ;

Lettre, Guillaume ;

Berndt, Sonja I. ;

Weedon, Michael N. ;

Rivadeneira, Fernando ;

Willer, Cristen J. ;

Jackson, Anne U. ;

Vedantam, Sailaja ;

Raychaudhuri, Soumya ;

Ferreira, Teresa ;

Wood, Andrew R. ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Speliotes, Elizabeth K. ;

Wheeler, Eleanor ;

Soranzo, Nicole ;

Park, Ju-Hyun ;

Yang, Jian ;

Gudbjartsson, Daniel ;

Heard-Costa, Nancy L. ;

Randall, Joshua C. ;

Qi, Lu ;

Smith, Albert Vernon ;

Maegi, Reedik ;

Pastinen, Tomi ;

Liang, Liming ;

Heid, Iris M. ;

Luan, Jian'an ;

Thorleifsson, Gudmar ;

Winkler, Thomas W. ;

Goddard, Michael E. ;

Lo, Ken Sin ;

Palmer, Cameron ;

Workalemahu, Tsegaselassie ;

Aulchenko, Yurii S. ;

Johansson, Asa ;

Zillikens, M. Carola ;

Feitosa, Mary F. ;

Esko, Tonu ;

Johnson, Toby ;

Ketkar, Shamika ;

Kraft, Peter ;

Mangino, Massimo ;

Prokopenko, Inga ;

Absher, Devin ;

Albrecht, Eva ;

Ernst, Florian ;

Glazer, Nicole L. ;

Hayward, Caroline .

NATURE, 2010, 467 (7317) :832-838

[3] Specific transcriptional changes in human fetuses with autosomal trisomies [J].

Altug-Teber, O. ;

Bonin, M. ;

Walter, M. ;

Mau-Holzmann, U. A. ;

Dufke, A. ;

Stappert, H. ;

Tekesin, I. ;

Heilbronner, H. ;

Nieselt, K. ;

Riess, O. .

CYTOGENETIC AND GENOME RESEARCH, 2007, 119 (3-4) :171-184

[4] Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia [J].

Aury, Jean-Marc ;

Jaillon, Olivier ;

Duret, Laurent ;

Noel, Benjamin ;

Jubin, Claire ;

Porcel, Betina M. ;

Segurens, Beatrice ;

Daubin, Vincent ;

Anthouard, Veronique ;

Aiach, Nathalie ;

Arnaiz, Olivier ;

Billaut, Alain ;

Beisson, Janine ;

Blanc, Isabelle ;

Bouhouche, Khaled ;

Camara, Francisco ;

Duharcourt, Sandra ;

Guigo, Roderic ;

Gogendeau, Delphine ;

Katinka, Michael ;

Keller, Anne-Marie ;

Kissmehl, Roland ;

Klotz, Catherine ;

Koll, France ;

Le Mouel, Anne ;

Lepere, Gersende ;

Malinsky, Sophie ;

Nowacki, Mariusz ;

Nowak, Jacek K. ;

Plattner, Helmut ;

Poulain, Julie ;

Ruiz, Francoise ;

Serrano, Vincent ;

Zagulski, Marek ;

Dessen, Philippe ;

Betermier, Mireille ;

Weissenbach, Jean ;

Scarpelli, Claude ;

Schaechter, Vincent ;

Sperling, Linda ;

Meyer, Eric ;

Cohen, Jean ;

Wincker, Patrick .

NATURE, 2006, 444 (7116) :171-178

[5] Multiple Paleopolyploidizations during the Evolution of the Compositae Reveal Parallel Patterns of Duplicate Gene Retention after Millions of Years [J].

Barker, Michael S. ;

Kane, Nolan C. ;

Matvienko, Marta ;

Kozik, Alexander ;

Michelmore, W. ;

Knapp, Steven J. ;

Rieseberg, Loren H. .

MOLECULAR BIOLOGY AND EVOLUTION, 2008, 25 (11) :2445-2455

[6] A rheostat model for a rapid and reversible form of imprinting-dependent evolution [J].

Beaudet, AL ;

Jiang, YH .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (06) :1389-1397

[7] Two-Phase Resolution of Polyploidy in the Arabidopsis Metabolic Network Gives Rise to Relative and Absolute Dosage Constraints [J].

Bekaert, Michael ;

Edger, Patrick P. ;

Pires, J. Chris ;

Conant, Gavin C. .

PLANT CELL, 2011, 23 (05) :1719-1728

[8] A continuum model for tumour suppression [J].

Berger, Alice H. ;

Knudson, Alfred G. ;

Pandolfi, Pier Paolo .

NATURE, 2011, 476 (7359) :163-169

[9] Dosage balance in gene regulation: biological implications [J].

Birchler, JA ;

Riddle, NC ;

Auger, DL ;

Veitia, RA .

TRENDS IN GENETICS, 2005, 21 (04) :219-226

[10]

BIRCHLER JA, 1981, GENETICS, V97, P625

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