Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35->p34.3 by fluorescence in situ hybridization

The human platelet-activating factor cell-surface receptor (PTAFR) is a G protein-coupled receptor thought to contribute to many atopic and inflammatory diseases and, perhaps, to the growth of some neoplasms. Exploring the possibility that the PTAFR might be involved in the genetic predisposition to any disease requires knowledge of its chromosomal localization. In this paper we have used a 20-kb human genomic fragment containing the coding sequence ofthe cloned PTAFR to determine the regional chromosomal localization of the gene. Using fluorescence in situ hybridization, the localization ofthe human PTAFR gene was mapped to lp35 --> p34.3.