Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

被引：14

作者：

Burns, Christopher J. ^{[1
]}

Harte, Michael F. ^{[1
]}

Bu, Xianyong ^{[1
]}

Fantino, Emmanuelle ^{[1
]}

Giarrusso, Marilena ^{[1
]}

Joffe, Max ^{[1
]}

Kurek, Margarita ^{[1
]}

Legge, Fiona S. ^{[1
]}

Razzino, Pasquale ^{[1
]}

Su, Stephen ^{[1
]}

Treutlein, Herbert ^{[1
]}

Wan, Soo San ^{[1
]}

Zeng, Jun ^{[1
]}

Wilks, Andrew F. ^{[1
]}

机构：

[1] Cytopia Res Pty Ltd, Richmond, Vic 3121, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 04期

关键词：

FMS; CSF-1R; M-CSF-1; CSF-1; Kinase inhibitor; Macrophage; COLONY-STIMULATING FACTOR; C-FMS; KINASE INHIBITORS; TYROSINE KINASE; MACROPHAGES; EXPRESSION; RECEPTOR; CELLS; DESIGN;

D O I：

10.1016/j.bmcl.2008.12.073

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-(alpha-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1206 / 1209

页数：4

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