Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort

被引：110

作者：

Chuang, Shu-Chun ^{[1
]}

Norat, Teresa ^{[1
]}

Murphy, Neil ^{[1
]}

Olsen, Anja ^{[2
]}

Tjonneland, Anne ^{[2
]}

Overvad, Kim ^{[3
]}

Boutron-Ruault, Marie Christine ^{[4
,5
]}

Perquier, Florence ^{[4
,5
]}

Dartois, Laureen ^{[4
,5
]}

Kaaks, Rudolf ^{[6
]}

Teucher, Birgit ^{[6
]}

Bergmann, Manuela M. ^{[7
]}

Boeing, Heiner ^{[7
]}

Trichopoulou, Antonia ^{[8
,9
]}

Lagiou, Pagona ^{[10
,11
]}

Trichopoulos, Dimitrios ^{[10
,11
]}

Grioni, Sara ^{[12
]}

Sacerdote, Carlotta ^{[13
,14
]}

Panico, Salvatore ^{[15
]}

Palli, Domenico ^{[16
]}

Tumino, Rosario

Peeters, Petra H. M. ^{[1
,17
]}

Bueno-de-Mesquita, Bas ^{[18
,19
]}

Ros, Martine M. ^{[18
,20
]}

Brustad, Magritt ^{[21
]}

Asli, Lene Angell ^{[21
]}

Skeie, Guri ^{[21
]}

Quiros, J. Ramon ^{[22
]}

Gonzalez, Carlos A. ^{[23
]}

Sanchez, Maria-Jose ^{[24
]}

Navarro, Carmen ^{[25
]}

Aicua, Eva Ardanaz ^{[26
]}

Dorronsoro, Miren ^{[27
]}

Drake, Isabel ^{[28
]}

Sonestedt, Emily ^{[28
]}

Johansson, Ingegerd ^{[29
]}

Hallmans, Goeran ^{[30
]}

Key, Timothy ^{[31
]}

Crowe, Francesca ^{[31
]}

Khaw, Kay-Tee ^{[32
]}

Wareham, Nicholas ^{[33
]}

Ferrari, Pietro ^{[34
]}

Slimani, Nadia ^{[34
]}

Romieu, Isabelle ^{[34
]}

Gallo, Valentina ^{[1
,35
]}

Riboli, Elio ^{[1
]}

Vineis, Paolo ^{[1
,14
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London W2 1PG, England

[2] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[3] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[4] Ctr Res Epidemiol & Publ Hlth, INSERM, Villejuif, France

[5] Paris S Univ, Villejuif, France

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] German Inst Human Nutr, Potsdam Rehbruecke Dept Epidemiol, Nuthetal, Germany

[8] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[9] Hellen Hlth Fdn, Athens, Greece

[10] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[11] Acad Athens, Bur Epidemiol Res, Athens, Greece

[12] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[13] CPO Piemonte, Turin, Italy

[14] HuGeF Fdn, Turin, Italy

[15] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[16] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[17] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[18] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[19] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[20] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands

[21] Univ Tromso, Dept Community Med, Tromso, Norway

[22] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[23] Catalan Inst Oncol, Canc Epidemiol Res Programme, Barcelona, Spain

[24] Andalusian Sch Publ Hlth, Granada, Spain

[25] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[26] Navarre Publ Hlth Inst, Pamplona, Spain

[27] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[28] Lund Univ, Dept Clin Sci Malmo, S-22100 Lund, Sweden

[29] Umea Univ, Dept Odontol, Umea, Sweden

[30] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[31] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[32] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[33] MRC Epidemiol Unit, Cambridge, England

[34] Int Agcy Res Canc, F-69372 Lyon, France

[35] London Sch Hyg & Trop Med, London WC1, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2012年 / 96卷 / 01期

基金：

英国医学研究理事会;

关键词：

CORONARY-HEART-DISEASE; DIETARY FIBER; COLORECTAL-CANCER; CARDIOVASCULAR-DISEASE; REGRESSION-MODELS; REDUCED RISK; ASSOCIATION; HEALTH; CALIBRATION; FOOD;

D O I：

10.3945/ajcn.111.028415

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background: Previous studies have shown that high fiber intake is associated with lower mortality. However, little is known about the association of dietary fiber with specific causes of death other than cardiovascular disease (CVD). Objective: The aim of this study was to assess the relation between fiber intake, mortality, and cause-specific mortality in a large European prospective study of 452,7 I 7 men and women. Design: HRs and 95% CIs were estimated by using Cox proportional hazards models, stratified by age, sex, and center and adjusted for education, smoking, alcohol consumption, BMI, physical activity, total energy intake, and, in women, ever use of menopausal hormone therapy. Results: During a mean follow-up of 12.7 y, a total of 23,582 deaths were recorded. Fiber intake was inversely associated with total mortality (HRper (10-g/d) (increase): 0.90; 95% Cl: 0.88, 0.92); with mortality from circulatory (HRper (10-g/d increase): 0.90 and 0.88 for men and women, respectively), digestive (HR: 0.61 and 0.64), respiratory (HR: 0.77 and 0.62), and non-CVD noncancer inflammatory (HR: 0.85 and 0.80) diseases; and with smoking-related cancers (HR: 0.86 and 0.89) but not with non-smoking-related cancers (HR: 1.05 and 0.97). The associations were more evident for fiber from cereals and vegetables than from fruit. The associations were similar across BMI and physical activity categories but were stronger in smokers and participants who consumed >18 g alcohol/d. Conclusions: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases. Our results support current recommendations of high dietary fiber intake for health maintenance. Am J Clin Nutr 2012;96:164-74.

引用

页码：164 / 174

页数：11

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