Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination

被引：294

作者：

Desmet, Christophe J. ^{[1
,4
]}

Ishii, Ken J. ^{[2
,3
]}

机构：

[1] Univ Liege, Lab Cellular & Mol Immunol, GIGA Res, B-4000 Liege, Belgium

[2] Osaka Univ, Lab Vaccine Sci, WPI Immunol Frontier Res Ctr IFREC, Suita, Osaka 5650871, Japan

[3] Natl Inst Biomed Innovat NIBIO, Lab Adjuvant Innovat, Ibaraki, Osaka, Japan

[4] Univ Liege, Fac Vet Med, B-4000 Liege, Belgium

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 07期

基金：

日本科学技术振兴机构;

关键词：

PLASMACYTOID DENDRITIC CELLS; TOLL-LIKE RECEPTORS; DOUBLE-STRANDED-RNA; YELLOW-FEVER VACCINE; PATTERN-RECOGNITION RECEPTORS; I INTERFERON RESPONSE; CYCLIC-DI-GMP; HUMAN B-CELLS; RIG-I; ANTIVIRAL RESPONSES;

D O I：

10.1038/nri3247

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. This Review first addresses our current understanding of the nucleic acid-sensing immune machinery. We then explain how the study of nucleic acid-sensing mechanisms not only has revealed their central role in driving the responses mediated by many current vaccines, but is also revealing how they could be harnessed for the design of new vaccines.

引用

页码：479 / 491

页数：13

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