Natural killer T (NKT) cells and their role in antitumor immunity

被引：87

作者：

Brutkiewicz, RR

Sriram, V

机构：

[1] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Walther Oncol Ctr, Indianapolis, IN 46202 USA

[3] Walther Canc Inst, Indianapolis, IN 46208 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2002年 / 41卷 / 03期

关键词：

NKT cells; CD1; antitumor; IL-12; glycolipids; cytokines;

D O I：

10.1016/S1040-8428(01)00198-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer T (NKT) cells have become a major focus for those who study the innate immune response to tumors and infectious diseases, as well as autoimmunity. These novel T lymphocytes produce both Th1 and Th2 cytokines, recognize phospholipid and glycolipid antigens presented by CD1 molecules in a similar manner as peptides are recognized by cytotoxic T lymphocytes (CTL), and kill tumor cell targets by a perforin-dependent mechanism like NK cells and CTL. These ascribed functions thus demonstrate that NKT cells are a unique cytotoxic effector cell subpopulation with a kaleidoscope of activities. Because they can mediate antitumor effects in vivo with or without the collaboration of NK cells, the study of NKT cells in antitumor immunity may lead to novel treatments based on the ability to manipulate the generation and/or activity of these multifunctional lymphocytes. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：287 / 298

页数：12

共 147 条

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