Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

被引：72

作者：

Han, QB

Wang, YL

Yang, L

Tso, TF

Qiao, CF

Song, JZ

Xu, LJ

Chen, SL

Yang, DJ

Xu, HX ^{[1
]}

机构：

[1] Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian 116023, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 02期

关键词：

Garcinia hanburyi; cytotoxicity; xanthone; multidrug resistance; gaudichaudic acid; isogambogenic acid;

D O I：

10.1248/cpb.54.265

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

引用

页码：265 / 267

页数：3

共 16 条

[1] Cytotoxic xanthones from Garcinia hanburyi [J].